This collection includes nineteen documents relating principally to the revolt of Tupac Amaru II (José Gabriel Condorcanqui), the last claimant to the throne of the Incas (1780-1783). The materials refer to his rebellion, capture, and execution. Other documents in the collection concern medicine, manners, learned organizations, the making of wills, and the history of the Spanish conquest of Oran, 1505-1509.

In addition to family and business correspondence, the Charles Nicoll Bancker Family Papers contains various documents, such as a furniture inventory volume (30pp.); a Daybook, 1795-1800 (120pp.); and a very interesting journal (unidentified, but by one of the Banckers, and filed under "Description of a trip..."), from New York to Albany and back, between July 20-Aug. 15, 1793 (1 vol., 31 pp.). It contains detailed observations of the Hudson River and the towns along the way. Bancker was involved in business and trade prior to 1826, and in insurance after that date, so there is material relating to those topics in this collection. He owned a substantial library of the period, which was used by Charles Wilkes's Expedition after 1837 (see Reynell Coates to Bancker). This library, along with Bancker's notable scientific instrument collection, was sold after his death and there are published auction catalogues in the collection. There is much family correspondence from: Anne E. Bancker, Charles Gerard Bancker, Evert Bancker, Sarah U. Bancker, Violetta Bancker Talbot, Elizabeth Bancker Teackle, and John Teackle.

Though the Miscellaneous Manuscripts collection is composed of items that do not fall readily into any other existing collection, the two dominant intellectual areas represented in the collection are Early American History and History of Science.